Notes
If mixing LAs, we recommend that the safest practice is not to exceed 100% of the combined maximum dose.1, 2
Levobupivacaine/Bupivacaine with adrenaline: A maximum dose of 3 mg/kg; not to exceed 225 mg per dose.3
Adrenaline: There were no differences in blood flow reduction between epinephrine concentrations of 1:100,000, 1:200,000, and 1:400,000.4 Based on a review of the literature, concentrations between 1:50,000 and 1:400,000 are equally effective and provide superior vasoconstriction compared with more dilute solutions.5
IBW: ideal body weight; LBW: lean body weight; BNF: British National Formulary; SOBA: The Society for Obesity and Bariatric Anaesthesia;
AoA: Association of Anaesthetists (UK); TKR: total knee replacement; LIA: local infiltration analgesia
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