Consider using ideal or adjusted body weight if BMI ≥30 kg/m².

Noradrenaline / Adrenaline

4 mg in 50 ml 0.08 mg/mL
8 mg in 50 ml 0.16 mg/mL
16 mg in 50 ml 0.32 mg/mL

Infusion rate: -

Vasopressin

20 units in 50 mL 0.4 units/mL

Infusion rate: -

Dose range 0.01–0.04 units/min / 0.5–2.4 units/hr.

Optimal vasopressin timing in septic shock lacks guidance. Guidelines suggest noradrenaline doses 0.25–0.50 mcg/kg/min.

Hydrocortisone

For adults with septic shock and an ongoing requirement for vasopressor therapy.

200 mg/24 hours: 50 mg IV every 6 hours or a continuous infusion.

Commenced at a dose of noradrenaline or adrenaline ≥0.25 mcg/kg/min at least 4 hours after initiation.